A “TripAdvisor” for chemical probes

If medicinists want to test a new drug, they can literally choose between hundreds or thousands of reported molecules. But the real problem they are here facing is the high number of ill-suited molecules, that are not properly described, e.g., compounds that target enzymes other than the desired one, or have unwanted side-effects. Finding a suitable drug for a biomedical study can thus take endless hours before the study itself has even started.

Chemical biologists have now used crowdfunding to start an internet platform that recommends chemical probes, as reported in Science News. This action is in my opinion a very exciting act of self-empowerment, based on the strong impression that the self-correction mechanisms in scientific publishing are not sufficent. I think, one underlying problem might also be the reproducibility crisis, science is still facing. Once a new compound is published, its reproduction (and cross-checking) by other labs is not feasible anymore, since the work would be not original. Problems in reproduction therefore usually occur when the compound is supposed to be used for an application.

Maybe ChemicalProbes.org has the potential to provide an alternative metric for science, based on the applicability of drugs and drug-like molecules.


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